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Single-base DNA discrimination via transverse ionic transport.

James Wilson, and Massimiliano Di Ventra
Nanotechnology 24(41) 415101 (2013)
DOI:10.1088/0957-4484/24/41/415101  PMID:24061386  BibTex

We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.